The 100-400mm f/4.5-5.6 is a classic design used by countless creatives for genres like sports and wildlife photography, where its versatile focal range and modest aperture offer a lot of reach at far more reasonable prices than top-shelf supertelephoto prime lenses. For Nikon mirrorless shooters, there is the NIKKOR Z 100-400mm f/4.5-5.6 VR S, and this great video review takes a look at the sort of performance and image quality you can expect from it in practice.